Which syndrome is known for both hearing loss and the association with cleft palate?

Stickler Syndrome is recognized for its association with hearing loss and cleft palate. This genetic condition affects connective tissue, leading to a variety of symptoms, including ocular problems, hearing impairment, and craniofacial abnormalities, such as cleft palate. The hearing loss in Stickler Syndrome can be conductive, due to structural changes in the ear, or sensorineural, related to the function of the auditory pathway.

In the context of other syndromes mentioned, Wolfram Syndrome primarily involves diabetes insipidus, diabetes mellitus, optic atrophy, and hearing loss, but it does not typically include cleft palate. Brachio-oto-renal Syndrome is associated with hearing loss and branchial or renal anomalies but is not directly linked to cleft palate. Wiskott-Aldrich Syndrome features immunodeficiency, eczema, and thrombocytopenia, with no typical association with cleft palate or significant hearing loss.

Thus, the hallmark features of Stickler Syndrome make it the correct answer as it encompasses both hearing loss and the presence of cleft palate among its characteristic manifestations.