Which symptom is NOT commonly associated with Leber's Hereditary Optic Neuropathy (LHON)?

Leber's Hereditary Optic Neuropathy (LHON) is primarily characterized by the sudden onset of central vision loss, which is often a profound and dramatic symptom typically occurring in young adults. It is linked to mutations in mitochondrial DNA, leading to the death of retinal ganglion cells and subsequent vision degradation.

Among the symptoms related to LHON, gradual central vision loss is the most prominent and well documented. While fatigue can sometimes be noted in patients with LHON, muscle twitches and seizures are not standard clinical descriptions associated with this condition. Instead, LHON focuses mainly on visual disturbances, primarily the loss of central vision, making the choice of muscle twitches particularly noncharacteristic for this hereditary optic neuropathy. This distinguishes it from other conditions that may present with neuromuscular symptoms, which further confirms that muscle twitches are not commonly associated with LHON.