Which of the following symptoms is NOT associated with Canavan Disease?

Canavan Disease is a genetic disorder that primarily affects the brain and is characterized by a deficiency of the enzyme aspartoacylase. This deficiency leads to the accumulation of N-acetylaspartic acid (NAA), which is toxic to brain cells, resulting in a range of neurological symptoms.

The correct response identifies jaundice as a symptom that is not associated with Canavan Disease. The most common symptoms of Canavan Disease include developmental delays, seizures, feeding issues, and macrocephaly. Macrocephaly, or an abnormally large head size, is a hallmark symptom due to the accumulation of fluid and brain atrophy. Feeding difficulties are often present as the infant may exhibit poor muscle tone and coordination, affecting their ability to eat.

Seizures are also a frequent occurrence in individuals with Canavan Disease, stemming from the neurological impact of the condition. However, jaundice, which is a yellowing of the skin and eyes often related to liver dysfunction or hemolytic conditions, is not a symptom related to this disease. It is more typically associated with liver issues or diseases affecting the breakdown of red blood cells, making it an incorrect choice in the context of Canavan Disease symptoms.