Which of the following is a common symptom associated with MECP2 Duplication Syndrome?

MECP2 Duplication Syndrome is primarily characterized by a range of neurological and developmental symptoms, among which severe intellectual disability is a prominent feature. This condition is caused by the duplication of the MECP2 gene, which plays a crucial role in the development and function of neurons. Individuals with this syndrome often exhibit challenges in cognitive functioning, which can manifest as significant limitations in intellectual development.

In addition to severe intellectual disability, patients may experience other symptoms such as developmental delays, speech and motor skill impairments, and various behavioral issues. Therefore, identifying severe intellectual disability as a common symptom helps to highlight the impact of MECP2 duplication on cognitive development and overall functioning in affected individuals. This understanding is critical for clinicians and genetic counselors in providing accurate diagnoses, therapy recommendations, and support for families.