Which factor is NOT commonly associated with CHARGE Syndrome manifestations?

CHARGE Syndrome is a complex genetic condition characterized by a range of congenital anomalies. It is associated with several common features, including vision impairment, heart defects, and genital hypoplasia.

Vision impairment is frequently observed in individuals with CHARGE Syndrome, stemming from eye abnormalities such as colobomas, which are gaps or defects in the structure of the eye.

Heart defects are also a prime feature of CHARGE Syndrome, with congenital heart issues being present in a significant number of affected individuals. These can include a variety of structural heart anomalies.

Genital hypoplasia is another characteristic manifestation of CHARGE Syndrome, often linked to developmental abnormalities in the reproductive organs, which are common in those with the condition.

In contrast, peripheral neuropathy is not a typical manifestation associated with CHARGE Syndrome. While some individuals with other genetic conditions may experience peripheral neuropathy due to various underlying mechanisms, it does not have a defined relationship with the features of CHARGE Syndrome. Therefore, this factor is the one that stands out as being less commonly associated with the manifestations of CHARGE.