What type of tumors are primarily associated with Peutz-Jeghers Syndrome?

Peutz-Jeghers Syndrome is primarily associated with hamartomatous polyps, which are benign growths that occur in various organs, particularly in the gastrointestinal tract. These polyps are characterized by an excessive growth of normal tissue that is native to the surrounding area, leading to a disorganized but benign mass. The development of these polyps usually begins in childhood and can lead to complications such as intestinal obstruction, but they are not inherently cancerous.

Individuals with Peutz-Jeghers Syndrome have a significantly increased risk of developing various types of cancers later in life, including gastrointestinal tract cancers and other malignancies, but the direct association with the syndrome itself primarily pertains to the hamartomatous polyps. The presence of these polyps is a hallmark feature and is part of the diagnostic criteria for Peutz-Jeghers Syndrome.

While other options mention different types of tumors or tissue growths, hamartomatous polyps are distinctly tied to the syndrome, emphasizing the genetic and phenotypic characteristics of Peutz-Jeghers Syndrome.