What neurological issue is commonly associated with Canavan Disease?

Canavan Disease is a genetic disorder caused by a deficiency in the enzyme aspartoacylase, which leads to the accumulation of N-acetylaspartate in the brain. This condition primarily affects the myelin in the brain, resulting in progressive neurodegeneration. A common neurological manifestation of Canavan Disease is seizures. These seizures typically arise due to the extensive neurological involvement and the resultant disturbances in normal brain activity.

Seizures can vary in type and severity and are often a fundamental aspect of the neurological issues experienced by individuals with Canavan Disease, which further complicates their overall health management.

In contrast, severe headaches, symptoms resembling Parkinson's, or those typical of Alzheimer’s do not represent the primary neurological manifestations seen in this condition. While various neurological symptoms can arise in different diseases, the association of seizures with Canavan Disease is well-documented and a key aspect of its clinical presentation.