What is the most common genetic cause of Hypertrophic Cardiomyopathy?

The most common genetic cause of Hypertrophic Cardiomyopathy (HCM) is indeed associated with the MYBPC3 gene. This gene encodes a cardiac protein called cardiac myosin-binding protein C, which plays a crucial role in the structure and function of cardiac muscle cells. Mutations in MYBPC3 are responsible for a significant proportion of inherited cases of HCM, making it a key focus in understanding the genetic underpinnings of the condition.

HCM is characterized by hypertrophy of the heart muscle, which can lead to complications such as heart failure and arrhythmias. The identification of mutations in MYBPC3 enables clinicians to provide better risk assessment and management for affected individuals and their families, underscoring the importance of genetic testing and counseling in cases of suspected HCM.

In contrast, while the other genes listed may be implicated in other disorders or conditions, they are not primarily associated with Hypertrophic Cardiomyopathy. HRAS, for instance, is more commonly linked to oncogenesis and certain syndromic conditions. IVD is involved in lysosomal storage disorders, and PTPN11 is associated with Noonan syndrome. Therefore, MYBPC3 remains the primary genetic factor associated with this specific cardiomy