What is the inheritance pattern of MEN2A?

The inheritance pattern of Multiple Endocrine Neoplasia Type 2A (MEN2A) is classified as autosomal dominant. This means that a single copy of the mutated gene inherited from an affected parent is sufficient to cause the disorder. In the case of MEN2A, mutations occur in the RET proto-oncogene, which is located on chromosome 10.

Individuals with MEN2A have a 50% chance of passing the mutated gene to each of their offspring, regardless of the offspring's sex. This pattern of inheritance is consistent with other autosomal dominant conditions where one mutated copy of the gene leads to a phenotypic expression of the disease.

Understanding the autosomal dominant inheritance pattern helps in genetic counseling, as it provides important information about the likelihood of disease development in children of affected individuals, and informs management and surveillance strategies for those at risk.