What is a significant risk associated with Nijmegen Breakage Syndrome?

Nijmegen Breakage Syndrome (NBS) is primarily associated with a predisposition to certain health conditions due to its underlying genetic cause. One of the most significant risks linked to NBS is the development of premature ovarian failure. This condition results from the genetic instability that characterizes NBS, leading to various reproductive issues. Women with NBS often experience age-related reproductive decline much earlier than their peers, which can affect their fertility, hormone balance, and overall reproductive health.

The other risks associated with NBS generally do not directly relate to ovarian function. While there may be associations with conditions like cancer or other metabolic issues, the most well-documented and widely recognized risk is indeed premature ovarian failure, making this the correct answer in the context of the question.