What is a common clinical manifestation of Sickle Cell Disease in children?

Dactylitis, also known as hand-foot syndrome, is a common and early clinical manifestation of Sickle Cell Disease in children. It typically presents as painful swelling of the hands and feet due to vaso-occlusive crises, where sickle-shaped red blood cells block blood flow in small blood vessels. This condition can be particularly pronounced in young children as their small bones are more likely to experience painful blockages.

While splenic sequestration is also a serious complication associated with Sickle Cell Disease, it is more of an acute event rather than a common early manifestation. Cholelithiasis can occur later in life due to increased bilirubin from the breakdown of sickle cells, but it is not a common early presentation in children. Jaundice, though a potential manifestation due to hemolysis, is less specific and can result from various conditions, making it not unique to Sickle Cell Disease alone.