What genetic condition is characterized by increased sensitivity to UV radiation?

Xeroderma pigmentosum is the condition characterized by increased sensitivity to UV radiation. This genetic disorder results from mutations in genes responsible for repairing DNA damage caused by ultraviolet light. Individuals with this condition are unable to effectively repair the DNA damage that UV exposure causes, leading to a heightened risk of skin cancers and other complications associated with UV radiation.

Xeroderma pigmentosum is an autosomal recessive disorder, and its symptoms typically manifest in childhood, with individuals developing freckling, sunburns, and skin cancers at a much higher frequency than the general population. The condition underscores the critical importance of DNA repair mechanisms in maintaining cellular integrity and protecting against carcinogenesis.

In contrast, other options listed do not have a direct relationship with UV sensitivity. Multiple Endocrine Neoplasia Type 1 involves tumors of the endocrine glands but is not associated with UV radiation sensitivity. Hereditary Paraganglioma-Pheochromocytoma Syndrome is a genetic condition linked to tumors in the adrenal glands and parasympathetic nervous system, with no involvement of UV sensitivity. DICER1 Syndrome is associated with various tumor types, particularly in children, and is related to mutations in the DICER1 gene, but again, it